Pharmacokinetics, Pharmacodynamics, and Tolerability of GS-9851, a Nucleotide Analog Polymerase Inhibitor, following Multiple Ascending Doses in Patients with Chronic Hepatitis C Infection

We conducted this double-blind, parallel-group, placebo-controlled, randomized, multiple-ascending-dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of GS-9851 (formerly PSI-7851) in treatment-naïve patients infected with hepatitis C virus (HCV) genotype 1. Thirty...

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Bibliographische Detailangaben
Hauptverfasser: Lawitz, Eric, Rodriguez-Torres, Maribel, Denning, Jill M., Albanis, Efsevia, Cornpropst, Melanie, Berrey, Michelle M., Symonds, William T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591915/
https://ncbi.nlm.nih.gov/pubmed/23263000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01263-12
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