Differential Influence of the Antiretroviral Pharmacokinetic Enhancers Ritonavir and Cobicistat on Intestinal P-Glycoprotein Transport and the Pharmacokinetic/Pharmacodynamic Disposition of Dabigatran

Dabigatran etexilate (DE) is a P-glycoprotein (P-gp) probe substrate, and its active anticoagulant moiety, dabigatran, is a substrate of the multidrug and toxin extrusion protein-1 (MATE-1) transporter. The antiretroviral pharmacokinetic enhancers, ritonavir and cobicistat, inhibit both these transp...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Kumar, Parag, Gordon, Lori A., Brooks, Kristina M., George, Jomy M., Kellogg, Anela, McManus, Maryellen, Alfaro, Raul M., Nghiem, Khanh, Lozier, Jay, Hadigan, Colleen, Penzak, Scott R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655101/
https://ncbi.nlm.nih.gov/pubmed/28848011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01201-17
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