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Positively Selected Sites in Cetacean Myoglobins Contribute to Protein Stability

Since divergence ∼50 Ma ago from their terrestrial ancestors, cetaceans underwent a series of adaptations such as a ∼10–20 fold increase in myoglobin (Mb) concentration in skeletal muscle, critical for increasing oxygen storage capacity and prolonging dive time. Whereas the O(2)-binding affinity of...

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Main Authors: Dasmeh, Pouria, Serohijos, Adrian W. R., Kepp, Kasper P., Shakhnovich, Eugene I.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591298/
https://ncbi.nlm.nih.gov/pubmed/23505347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002929
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