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Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability

Protein abundance affects the evolution of protein genotypes, but we do not know how it affects the evolution of protein phenotypes. Here we investigate the role of protein abundance on the evolvability of green fluorescent protein (GFP) towards the novel phenotype of cyan fluorescence. We evolve GF...

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Bibliografiske detaljer
Udgivet i:Nat Ecol Evol
Main Authors: Karve, Shraddha, Dasmeh, Pouria, Zheng, Jia, Wagner, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: 2022
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613228/
https://ncbi.nlm.nih.gov/pubmed/35798838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41559-022-01797-w
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