A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan

Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard and a laboratory strain. The predominant QTL m...

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Autors principals: Kwan, Elizabeth X., Foss, Eric J., Tsuchiyama, Scott, Alvino, Gina M., Kruglyak, Leonid, Kaeberlein, Matt, Raghuraman, M. K., Brewer, Bonita J., Kennedy, Brian K., Bedalov, Antonio
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591295/
https://ncbi.nlm.nih.gov/pubmed/23505383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003329
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