A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan

Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard and a laboratory strain. The predominant QTL m...

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Detalhes bibliográficos
Main Authors: Kwan, Elizabeth X., Foss, Eric J., Tsuchiyama, Scott, Alvino, Gina M., Kruglyak, Leonid, Kaeberlein, Matt, Raghuraman, M. K., Brewer, Bonita J., Kennedy, Brian K., Bedalov, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591295/
https://ncbi.nlm.nih.gov/pubmed/23505383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003329
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