The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase

[Image: see text] Dihydrofolate reductase has long been used as a model system to study the coupling of protein motions to enzymatic hydride transfer. By studying environmental effects on hydride transfer in dihydrofolate reductase (DHFR) from the cold-adapted bacterium Moritella profunda (MpDHFR) a...

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Main Authors: Loveridge, E. Joel, Tey, Lai-Hock, Behiry, Enas M., Dawson, William M., Evans, Rhiannon M., Whittaker, Sara B.-M., Günther, Ulrich L., Williams, Christopher, Crump, Matthew P., Allemann, Rudolf K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590880/
https://ncbi.nlm.nih.gov/pubmed/22060818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja208844j
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