Vitreous TIMP-1 levels associate with neovascularization and TGF-β2 levels but not with fibrosis in the clinical course of proliferative diabetic retinopathy

In proliferative diabetic retinopathy (PDR), vascular endothelial growth factor (VEGF) and CCN2 (connective tissue growth factor; CTGF) cause blindness by neovascularization and subsequent fibrosis. This angio-fibrotic switch is associated with a shift in the balance between vitreous levels of CCN2...

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Main Authors: Van Geest, Rob J., Klaassen, Ingeborg, Lesnik-Oberstein, Sarit Y., Tan, H. Stevie, Mura, Marco, Goldschmeding, Roel, Van Noorden, Cornelis J. F., Schlingemann, Reinier O.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590360/
https://ncbi.nlm.nih.gov/pubmed/23054594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-012-0178-y
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