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A novel role for the mitochondrial HTRA2/OMI protease in aging

HTRA2/OMI is an ATP-independent serine protease located in the intermembrane space of the mitochondria and is thought to function as a protein quality control protease. Our previous studies showed that loss of the enzymatic activity of HTRA2 due to a Ser276Cys missense mutation in its catalytic doma...

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Bibliographic Details
Main Authors: Kang, Seokwon, Fernandes-Alnemri, Teresa, Alnemri, Emad S.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590264/
https://ncbi.nlm.nih.gov/pubmed/23242108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.22920
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