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Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
mnd2 mice die prematurely as a result of neurodegeneration 30–40 days after birth due to loss of the enzymatic activity of the mitochondrial quality control protease HtrA2/Omi. Here, we show that transgenic expression of human HtrA2/Omi in the central nervous system of mnd2 mice rescues them from ne...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554338/ https://ncbi.nlm.nih.gov/pubmed/22976834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.117 |
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