Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging

mnd2 mice die prematurely as a result of neurodegeneration 30–40 days after birth due to loss of the enzymatic activity of the mitochondrial quality control protease HtrA2/Omi. Here, we show that transgenic expression of human HtrA2/Omi in the central nervous system of mnd2 mice rescues them from ne...

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Bibliografske podrobnosti
Main Authors: Kang, S, Louboutin, J-P, Datta, P, Landel, C P, Martinez, D, Zervos, A S, Strayer, D S, Fernandes-Alnemri, T, Alnemri, E S
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
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Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554338/
https://ncbi.nlm.nih.gov/pubmed/22976834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.117
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