RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes

BACKGROUND: The RUNX1 (AML1) gene is a frequent mutational target in myelodysplastic syndromes and acute myeloid leukemia. Previous studies suggested that RUNX1 mutations may have pathological and prognostic implications. DESIGN AND METHODS: We screened 93 patients with cytogenetically normal acute...

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Библиографические подробности
Главные авторы: Greif, Philipp A., Konstandin, Nikola P., Metzeler, Klaus H., Herold, Tobias, Pasalic, Zlatana, Ksienzyk, Bianka, Dufour, Annika, Schneider, Friederike, Schneider, Stephanie, Kakadia, Purvi M., Braess, Jan, Sauerland, Maria Cristina, Berdel, Wolfgang E., Büchner, Thomas, Woermann, Bernhard J., Hiddemann, Wolfgang, Spiekermann, Karsten, Bohlander, Stefan K.
Формат: Artigo
Язык:Inglês
Опубликовано: Ferrata Storti Foundation 2012
Предметы:
Original Articles and Brief Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590097/
https://ncbi.nlm.nih.gov/pubmed/22689681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.064667
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