A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation

BACKGROUND: There is evidence suggesting that sirolimus, in combination with tacrolimus, is active in the prevention of graft-versus-host disease. Sirolimus-based immune suppression may suppress alloreactive T cells, while sparing the survival and function of regulatory T cells. DESIGN AND METHODS:...

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Detalhes bibliográficos
Main Authors: Pidala, Joseph, Kim, Jongphil, Jim, Heather, Kharfan-Dabaja, Mohamed A., Nishihori, Taiga, Fernandez, Hugo F., Tomblyn, Marcie, Perez, Lia, Perkins, Janelle, Xu, Mian, Janssen, William E., Veerapathran, Anandaraman, Betts, Brian C., Locke, Frederick L., Ayala, Ernesto, Field, Teresa, Ochoa, Leonel, Alsina, Melissa, Anasetti, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2012
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590095/
https://ncbi.nlm.nih.gov/pubmed/22689677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.067140
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