A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation

BACKGROUND: There is evidence suggesting that sirolimus, in combination with tacrolimus, is active in the prevention of graft-versus-host disease. Sirolimus-based immune suppression may suppress alloreactive T cells, while sparing the survival and function of regulatory T cells. DESIGN AND METHODS:...

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Main Authors: Pidala, Joseph, Kim, Jongphil, Jim, Heather, Kharfan-Dabaja, Mohamed A., Nishihori, Taiga, Fernandez, Hugo F., Tomblyn, Marcie, Perez, Lia, Perkins, Janelle, Xu, Mian, Janssen, William E., Veerapathran, Anandaraman, Betts, Brian C., Locke, Frederick L., Ayala, Ernesto, Field, Teresa, Ochoa, Leonel, Alsina, Melissa, Anasetti, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2012
Fag:
Original Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590095/
https://ncbi.nlm.nih.gov/pubmed/22689677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.067140
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