Bone Marrow-Derived Heparan Sulfate Potentiates The Osteogenic Activity Of Bone Morphogenetic Protein-2 (BMP-2)

Lowering the efficacious dose of bone morphogenetic protein-2 (BMP-2) for the repair of critical-sized bone defects is highly desirable, as supra-physiological amounts of BMP-2 have an increased risk of side effects and a greater economic burden for the healthcare system. To address this need, we ex...

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Main Authors: Bramono, Diah S., Murali, Sadasivam, Rai, Bina, Ling, Ling, Poh, Wei Theng, Lim, Zophia Xuehui, Stein, Gary S., Nurcombe, Victor, van Wijnen, Andre J., Cool, Simon M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589980/
https://ncbi.nlm.nih.gov/pubmed/22227436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2011.12.013
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