Hexosamine Biosynthesis Impairs Insulin Action via a Cholesterolgenic Response

Plasma membrane cholesterol accumulation has been implicated in cellular insulin resistance. Given the role of the hexosamine biosynthesis pathway (HBP) as a sensor of nutrient excess, coupled to its involvement in the development of insulin resistance, we delineated whether excess glucose flux thro...

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Bibliografiske detaljer
Main Authors: Penque, Brent A., Hoggatt, April M., Herring, B. Paul, Elmendorf, Jeffrey S.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589672/
https://ncbi.nlm.nih.gov/pubmed/23315940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1213
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