Hexosamine Biosynthesis Pathway Flux Contributes to Insulin Resistance via Altering Membrane Phosphatidylinositol 4,5-Bisphosphate and Cortical Filamentous Actin

We recently found that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) polymerization was diminished in hyperinsulinemic cell culture models of insulin resistance. Here we delineated whether increased glucose flux through the hexosamine biosynthes...

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Detalhes bibliográficos
Main Authors: Bhonagiri, Padma, Pattar, Guruprasad R., Horvath, Emily M., Habegger, Kirk M., McCarthy, Alicia M., Elmendorf, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659275/
https://ncbi.nlm.nih.gov/pubmed/19036880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-1102
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