Evidence Coupling Increased Hexosamine Biosynthesis Pathway Activity to Membrane Cholesterol Toxicity and Cortical Filamentous Actin Derangement Contributing to Cellular Insulin Resistance(†)

Hyperinsulinemia is known to promote the progression/worsening of insulin resistance. Evidence reveals a hidden cost of hyperinsulinemia on plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) structure, components critical to the normal operation...

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Main Authors: Bhonagiri, Padma, Pattar, Guruprasad R., Habegger, Kirk M., McCarthy, Alicia M., Tackett, Lixuan, Elmendorf, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2011
Assuntos:
Diabetes-Insulin-Glucagon-Gastrointestinal
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159786/
https://ncbi.nlm.nih.gov/pubmed/21712361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1295
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