DAXX-dependent supply of soluble (H3.3–H4) dimers to PML bodies pending deposition into chromatin

Replication-independent chromatin deposition of histone variant H3.3 is mediated by several chaperones. We report a multistep targeting of newly synthesized epitope-tagged H3.3 to chromatin via PML bodies. H3.3 is recruited to PML bodies in a DAXX-dependent manner, a process facilitated by ASF1A. DA...

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Main Authors: Delbarre, Erwan, Ivanauskiene, Kristina, Küntziger, Thomas, Collas, Philippe
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2013
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589533/
https://ncbi.nlm.nih.gov/pubmed/23222847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.142703.112
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