Regulation of ASPP2 Interaction with p53 Core Domain by an Intramolecular Autoinhibitory Mechanism

ASPP2 is a key protein in regulating apoptosis both in p53-dependent and-independent pathways. The C-terminal part of ASPP2 contains four ankyrin repeats and an SH3 domain (Ank-SH3) that mediate the interactions of ASPP2 with apoptosis related proteins such as p53, Bcl-2 and the p65 subunit of NFκB....

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Bibliographic Details
Main Authors: Rotem-Bamberger, Shahar, Katz, Chen, Friedler, Assaf
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589414/
https://ncbi.nlm.nih.gov/pubmed/23472201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058470
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