Mechanism of the Interaction between the Intrinsically Disordered C-Terminus of the Pro-Apoptotic ARTS Protein and the Bir3 Domain of XIAP

ARTS (Sept4_i2) is a mitochondrial pro-apoptotic protein that functions as a tumor suppressor. Its expression is significantly reduced in leukemia and lymphoma patients. ARTS binds and inhibits XIAP (X-linked Inhibitor of Apoptosis protein) by interacting with its Bir3 domain. ARTS promotes degradat...

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Main Authors: Reingewertz, Tali H., Shalev, Deborah E., Sukenik, Shahar, Blatt, Ofrah, Rotem-Bamberger, Shahar, Lebendiker, Mario, Larisch, Sarit, Friedler, Assaf
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176765/
https://ncbi.nlm.nih.gov/pubmed/21949740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024655
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