Degradation of Bcl-2 by XIAP and ARTS promotes apoptosis

We describe a mechanism by which the anti-apoptotic B-cell lymphoma 2 (Bcl-2) protein is down-regulated to induce apoptosis. ARTS (Sept4_i2) is a tumor suppressor protein that promotes cell death through specifically antagonizing XIAP (X linked Inhibitor of Apoptosis). ARTS and Bcl-2 reside at the o...

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Publicado en:Cell Rep
Autores principales: Edison, Natalia, Curtz, Yael, Paland, Nicole, Mamriev, Dana, Chorubczyk, Nicolas, Reingewertz, Tali Haviv, Kfir, Nir, Morgenstern, David, Kupervaser, Meital, Kagan, Juliana, Kim, Hyoung Tae, Larisch, Sarit
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667555/
https://ncbi.nlm.nih.gov/pubmed/29020630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.052
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