A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2

Many human cancers over-express B cell lymphoma 2 (Bcl-2) or X-linked inhibitor of apoptosis (IAP) proteins to evade cell death. The pro-apoptotic ARTS (Sept4_i2) protein binds directly to both Bcl-2 and XIAP and promotes apoptosis by stimulating their degradation via the ubiquitin-proteasome system...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Mamriev, Dana, Abbas, Ruqaia, Klingler, Franca-Maria, Kagan, Juliana, Kfir, Nir, Donald, Alastair, Weidenfeld, Keren, Sheppard, David W., Barkan, Dalit, Larisch, Sarit
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316745/
https://ncbi.nlm.nih.gov/pubmed/32587235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2670-2
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