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A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2
Many human cancers over-express B cell lymphoma 2 (Bcl-2) or X-linked inhibitor of apoptosis (IAP) proteins to evade cell death. The pro-apoptotic ARTS (Sept4_i2) protein binds directly to both Bcl-2 and XIAP and promotes apoptosis by stimulating their degradation via the ubiquitin-proteasome system...
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| Veröffentlicht in: | Cell Death Dis |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7316745/ https://ncbi.nlm.nih.gov/pubmed/32587235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2670-2 |
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