Effective Treatment of an Orthotopic Xenograft Model of Human Glioblastoma Using an EGFR-retargeted Oncolytic Herpes Simplex Virus

Glioblastoma multiforme (GBM) remains an untreatable human brain malignancy. Despite promising preclinical studies using oncolytic herpes simplex virus (oHSV) vectors, efficacy in patients has been limited by inefficient virus replication in tumor cells. This disappointing outcome can be attributed...

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Autori principali: Uchida, Hiroaki, Marzulli, Marco, Nakano, Kenji, Goins, William F, Chan, Janet, Hong, Chang-Sook, Mazzacurati, Lucia, Yoo, Ji Young, Haseley, Amy, Nakashima, Hiroshi, Baek, Hyunjung, Kwon, Heechung, Kumagai, Izumi, Kuroki, Masahide, Kaur, Balveen, Chiocca, E Antonio, Grandi, Paola, Cohen, Justus B, Glorioso, Joseph C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589172/
https://ncbi.nlm.nih.gov/pubmed/23070115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.211
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