Bispecific Adapter-Mediated Retargeting of a Receptor-Restricted HSV-1 Vector to CEA-Bearing Tumor Cells

The safety and efficacy of viral therapies for solid tumors can be enhanced by redirecting the virus infection to tumor-specific cell-surface markers. Successful retargeting of herpes simplex virus type 1 (HSV-1) has been achieved using vectors that carry a modified envelope glycoprotein D (gD) engi...

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Detalhes bibliográficos
Main Authors: Baek, Hyunjung, Uchida, Hiroaki, Jun, Kyungok, Kim, Jae-Hong, Kuroki, Masahide, Cohen, Justus B, Glorioso, Joseph C, Kwon, Heechung
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048173/
https://ncbi.nlm.nih.gov/pubmed/20924362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.207
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