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Effective Treatment of an Orthotopic Xenograft Model of Human Glioblastoma Using an EGFR-retargeted Oncolytic Herpes Simplex Virus
Glioblastoma multiforme (GBM) remains an untreatable human brain malignancy. Despite promising preclinical studies using oncolytic herpes simplex virus (oHSV) vectors, efficacy in patients has been limited by inefficient virus replication in tumor cells. This disappointing outcome can be attributed...
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| Prif Awduron: | , , , , , , , , , , , , , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
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Nature Publishing Group
2013
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3589172/ https://ncbi.nlm.nih.gov/pubmed/23070115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.211 |
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