Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A.

The ret oncogene frequently has been found activated in papillary thyroid carcinomas. A previous characterization of ret activation revealed recombination of its tyrosine kinase domain and sequences derived from an uncharacterized locus (D10S170). The mechanism leading to this recombination was iden...

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Autores principales: Bongarzone, I, Monzini, N, Borrello, M G, Carcano, C, Ferraresi, G, Arighi, E, Mondellini, P, Della Porta, G, Pierotti, M A
Formato: Artigo
Lenguaje:Inglês
Publicado: 1993
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC358915/
https://ncbi.nlm.nih.gov/pubmed/7678053
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