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Chimeragenesis of distantly-related proteins by noncontiguous recombination
We introduce a method for identifying elements of a protein structure that can be shuffled to make chimeric proteins from two or more homologous parents. Formulating recombination as a graph-partitioning problem allows us to identify noncontiguous segments of the sequence that should be inherited to...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3588919/ https://ncbi.nlm.nih.gov/pubmed/23225662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2202 |
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