Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.

A potent and specific small molecule inhibitor of farnesyl-protein transferase, L-739,749, caused rapid morphological reversion and growth inhibition of ras-transformed fibroblasts (Rat1/ras cells). Morphological reversion occurred within 18 h of L-739,749 addition. The reverted phenotype was stable...

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Main Authors: Prendergast, G C, Davide, J P, deSolms, S J, Giuliani, E A, Graham, S L, Gibbs, J B, Oliff, A, Kohl, N E
Formato: Artigo
Idioma:Inglês
Publicado: 1994
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC358785/
https://ncbi.nlm.nih.gov/pubmed/8196657
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