Insulin degradation by acinar-cell proteases creates a dysfunctional environment for human islets before/after transplantation: Benefits of alpha-1 antitrypsin treatment

BACKGROUND: Pancreatic acinar cells are commonly co-transplanted along with islets during auto-and allo-transplantations. The aims of this study were to identify how acinar cell proteases cause human islet cell loss before and after transplantation of impure islet preparations and to prevent islet l...

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主要な著者: Loganathan, Gopalakrishnan, Dawra, Rajinder K., Pugazhenthi, Subbiah, Guo, Zhiguang, Soltani, Sajjad M., Wiseman, Alexander, Sanders, Mark A., papas, Klearchos K., Kumaravel, V., Saluja, Ashok K., Sutherland, David E.R., Hering, Bernhard J., Balamurugan, A. N.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587768/
https://ncbi.nlm.nih.gov/pubmed/22089666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e318237585c
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