Insulin degradation by acinar-cell proteases creates a dysfunctional environment for human islets before/after transplantation: Benefits of alpha-1 antitrypsin treatment

BACKGROUND: Pancreatic acinar cells are commonly co-transplanted along with islets during auto-and allo-transplantations. The aims of this study were to identify how acinar cell proteases cause human islet cell loss before and after transplantation of impure islet preparations and to prevent islet l...

Full description

Saved in:
Bibliographic Details
Main Authors: Loganathan, Gopalakrishnan, Dawra, Rajinder K., Pugazhenthi, Subbiah, Guo, Zhiguang, Soltani, Sajjad M., Wiseman, Alexander, Sanders, Mark A., papas, Klearchos K., Kumaravel, V., Saluja, Ashok K., Sutherland, David E.R., Hering, Bernhard J., Balamurugan, A. N.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587768/
https://ncbi.nlm.nih.gov/pubmed/22089666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e318237585c
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items