Insulin degradation by acinar-cell proteases creates a dysfunctional environment for human islets before/after transplantation: Benefits of alpha-1 antitrypsin treatment

BACKGROUND: Pancreatic acinar cells are commonly co-transplanted along with islets during auto-and allo-transplantations. The aims of this study were to identify how acinar cell proteases cause human islet cell loss before and after transplantation of impure islet preparations and to prevent islet l...

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Detalhes bibliográficos
Main Authors: Loganathan, Gopalakrishnan, Dawra, Rajinder K., Pugazhenthi, Subbiah, Guo, Zhiguang, Soltani, Sajjad M., Wiseman, Alexander, Sanders, Mark A., papas, Klearchos K., Kumaravel, V., Saluja, Ashok K., Sutherland, David E.R., Hering, Bernhard J., Balamurugan, A. N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587768/
https://ncbi.nlm.nih.gov/pubmed/22089666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e318237585c
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