Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming

Previous studies have revealed that mouse primordial germ cells (PGCs) undergo genome-wide DNA methylation reprogramming to reset the epigenome for totipotency. However, the precise 5-methylcytosine (5mC) dynamics and its relationship with the generation of 5-hydroxymethylcytosine (5hmC) are not cle...

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Bibliographische Detailangaben
Hauptverfasser: Yamaguchi, Shinpei, Hong, Kwonho, Liu, Rui, Inoue, Azusa, Shen, Li, Zhang, Kun, Zhang, Yi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587712/
https://ncbi.nlm.nih.gov/pubmed/23399596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.22
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