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Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics
TET dioxygenases successively oxidize 5-methylcytosine (5mC) in mammalian genomes to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC/5caC can be excised and repaired to regenerate unmodified cytosines by thymine-DNA glycosylase (TDG) and base excision repai...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687516/ https://ncbi.nlm.nih.gov/pubmed/23602152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.04.002 |
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