Mitochondrial topoisomerase II activity is essential for kinetoplast DNA minicircle segregation.
Etoposide, a nonintercalating antitumor drug, is a potent inhibitor of topoisomerase II activity. When Trypanosoma equiperdum is treated with etoposide, cleavable complexes are stabilized between topoisomerase II and kinetoplast DNA minicircles, a component of trypanosome mitochondrial DNA (T. A. Sh...
Kaydedildi:
| Yayımlandı: | Mol Cell Biol |
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| Yazar: | |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Taylor & Francis
1994
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358733/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8196610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.6.3660-3667.1994 |
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