Kinetoplast-associated DNA topoisomerase in Crithidia fasciculata: crosslinking of mitochondrial topoisomerase II to both minicircles and maxicircles in cells treated with the topoisomerase inhibitor VP16.

The mitochondrial DNA of the trypanosomatid Crithidia fasciculata consists of thousands of copies of a 2.5 kb minicircle and a small number of 37kb maxicircles catenated into a single enormous network. Treatment of C. fasciculata with the type II DNA topoisomerase inhibitor VP16 produces cleavable c...

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Hauptverfasser: Ray, D S, Hines, J C, Anderson, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC312488/
https://ncbi.nlm.nih.gov/pubmed/1321413
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