Mitochondrial topoisomerase II activity is essential for kinetoplast DNA minicircle segregation.

Etoposide, a nonintercalating antitumor drug, is a potent inhibitor of topoisomerase II activity. When Trypanosoma equiperdum is treated with etoposide, cleavable complexes are stabilized between topoisomerase II and kinetoplast DNA minicircles, a component of trypanosome mitochondrial DNA (T. A. Sh...

Полное описание

Библиографические подробности

Опубликовано в::	Mol Cell Biol
Главный автор:	Shapiro, T A
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis 1994
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358733/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8196610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.6.3660-3667.1994
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