Sickle hemoglobin disturbs normal coupling among erythrocyte O(2) content, glycolysis, and antioxidant capacity

Energy metabolism in RBCs is characterized by O(2)-responsive variations in flux through the Embden Meyerhof pathway (EMP) or the hexose monophosphate pathway (HMP). Therefore, the generation of ATP, NADH, and 2,3-DPG (EMP) or NADPH (HMP) shift with RBC O(2) content because of competition between de...

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Main Authors: Rogers, Stephen C., Ross, Jerlinda G. C., d'Avignon, Andre, Gibbons, Lindsey B., Gazit, Vered, Hassan, Mojibade N., McLaughlin, Dylan, Griffin, Sherraine, Neumayr, Tara, DeBaun, Malcolm, DeBaun, Michael R., Doctor, Allan
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2013
Ábhair:
Red Cells, Iron, and Erythropoiesis
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587328/
https://ncbi.nlm.nih.gov/pubmed/23297128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-414037
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