Selective capacity of metreleptin administration to reconstitute CD4(+) T-cell number in females with acquired hypoleptinemia

Leptin is an adipocyte-derived hormone that controls food intake and reproductive and immune functions in rodents. In uncontrolled human studies, low leptin levels are associated with impaired immune responses and reduced T-cell counts; however, the effects of leptin replacement on the adaptive immu...

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Detalhes bibliográficos
Main Authors: Matarese, Giuseppe, La Rocca, Claudia, Moon, Hyun-Seuk, Huh, Joo Young, Brinkoetter, Mary T., Chou, Sharon, Perna, Francesco, Greco, Dario, Kilim, Holly P., Gao, Chuanyun, Arampatzi, Kalliope, Wang, Zhaoxi, Mantzoros, Christos S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587204/
https://ncbi.nlm.nih.gov/pubmed/23382191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214554110
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