Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance

OBJECTIVE: Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: We studied the role of leptin in regulating the endocrine adaptation to long-term calor...

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Bibliographic Details
Main Authors: Moon, Hyun-Seuk, Matarese, Giuseppe, Brennan, Aoife M., Chamberland, John P., Liu, Xiaowen, Fiorenza, Christina G., Mylvaganam, Geetha H., Abanni, Luisa, Carbone, Fortunata, Williams, Catherine J., De Paoli, Alex M., Schneider, Benjamin E., Mantzoros, Christos S.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2011
Subjects:
Perspectives in Diabetes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114380/
https://ncbi.nlm.nih.gov/pubmed/21617185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1791
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