Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food anaphylaxis

BACKGROUND: Sensitization to food antigen may occur through cutaneous exposure. OBJECTIVE: Test the hypothesis that epicutaneous (EC) sensitization with food antigen predisposes to IgE-mediated anaphylaxis upon oral allergen challenge. METHODS: BALB/c mice were EC sensitized by repeated application...

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Hlavní autoři: Bartnikas, Lisa M., Gurish, Michael F., Burton, Oliver T., Leisten, Sabine, Janssen, Erin, Oettgen, Hans C., Beaupré, Jacqueline, Lewis, Christopher N., Austen, K. Frank, Schulte, Stephanie, Hornick, Jason L., Geha, Raif S., Oyoshi, Michiko K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587010/
https://ncbi.nlm.nih.gov/pubmed/23374269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2012.11.032
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