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Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin

Patients with atopic dermatitis (AD) often suffer from food allergy and develop flares upon skin contact with food allergens. However, it is unclear whether T cells sensitized to allergens in the gut promote this skin inflammation. To address this question, we orally immunized WT mice and mice lacki...

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Detalhes bibliográficos
Main Authors: Oyoshi, Michiko K., Elkhal, Abdallah, Scott, Jordan E., Wurbel, Marc-Andre, Hornick, Jason L., Campbell, James J., Geha, Raif S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105371/
https://ncbi.nlm.nih.gov/pubmed/21537081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43586
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