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Fingolimod Reduces Hemorrhagic Transformation Associated With Delayed tPA Treatment In A Mouse Thromboembolic Model
BACKGROUND AND PURPOSE: The sphingosine 1-phosphate receptor agonist fingolimod reduces infarct size in rodent models of stroke and enhances Blood Brain Barrier (BBB) integrity. Based on these observations, we hypothesized that combination of fingolimod with tissue Plasminogen Activator (tPA) would...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3586809/ https://ncbi.nlm.nih.gov/pubmed/23287783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.112.679043 |
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