Fingolimod Reduces Hemorrhagic Transformation Associated With Delayed tPA Treatment In A Mouse Thromboembolic Model

BACKGROUND AND PURPOSE: The sphingosine 1-phosphate receptor agonist fingolimod reduces infarct size in rodent models of stroke and enhances Blood Brain Barrier (BBB) integrity. Based on these observations, we hypothesized that combination of fingolimod with tissue Plasminogen Activator (tPA) would...

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Hlavní autoři: Campos, Francisco, Qin, Tao, Castillo, José, Seo, Ji Hae, Arai, Ken, Lo, Eng H., Waeber, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586809/
https://ncbi.nlm.nih.gov/pubmed/23287783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.112.679043
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