Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas

Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide (TMZ) and therapeutic drugs. WW domain-containing oxidoreductase WWOX (FOR or WOX1) is a proapoptotic protein and is considered as a tumor suppressor. Loss of WWOX ge...

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Detaylı Bibliyografya
Asıl Yazarlar: Chiang, Ming-Fu, Chou, Pei-Yi, Wang, Wan-Jen, Sze, Chun-I, Chang, Nan-Shan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2013
Konular:
Oncology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586680/
https://ncbi.nlm.nih.gov/pubmed/23459853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00043
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