Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas

Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide (TMZ) and therapeutic drugs. WW domain-containing oxidoreductase WWOX (FOR or WOX1) is a proapoptotic protein and is considered as a tumor suppressor. Loss of WWOX ge...

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Detalles Bibliográficos
Autores principales: Chiang, Ming-Fu, Chou, Pei-Yi, Wang, Wan-Jen, Sze, Chun-I, Chang, Nan-Shan
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586680/
https://ncbi.nlm.nih.gov/pubmed/23459853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00043
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