Gadolinium MRI Contrast Agents Based on Triazine Dendrimers: Relaxivity and In Vivo Pharmacokinetics

Four gadolinium (Gd)-based macromolecular contrast agents, G3-(Gd-DOTA)(24), G5-(Gd-DOTA)(96), G3-(Gd-DTPA)(24), and G5-(Gd-DTPA)(96), were prepared that varied in the size of dendrimer (generation three and five), the type of chelate group (DTPA or DOTA), and the theoretical number of metallated ch...

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Autores principales: Lim, Jongdoo, Turkbey, Baris, Bernardo, Marcelino, Bryant, L. Henry, Garzoni, Matteo, Pavan, Giovanni M., Nakajima, Takahito, Choyke, Peter L., Simanek, Eric E., Kobayashi, Hisataka
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586605/
https://ncbi.nlm.nih.gov/pubmed/23035964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc300461r
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