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Dendrimer-Based MRI Contrast Agents: The Effects of PEGylation on Relaxivity and Pharmacokinetics
Polyethylene glycol (PEG)-surface modification can make nano-materials highly hydrophilic, reducing sequestration in the reticuloendothelial system. In this study, polyamidoamine (PAMAM) dendrimers bearing gadolinium chelates were PEGylated with different PEG-chain lengths and the effects on paramag...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3159711/ https://ncbi.nlm.nih.gov/pubmed/21515406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2011.03.007 |
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