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Antitumor Activity and Molecular Dynamics Simulations of Paclitaxel-Laden Triazine Dendrimers
The antitumor activities of triazine dendrimers bearing paclitaxel, a well-known mitotic inhibitor, are evaluated in SCID mice bearing human prostate cancer xenografts. To increase the activity of a first generation prodrug 1 that contained twelve paclitaxel molecules tethered via an ester linkage,...
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| Publicado en: | Mol Pharm |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7768605/ https://ncbi.nlm.nih.gov/pubmed/22260328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp2005017 |
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