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Antitumor Activity and Molecular Dynamics Simulations of Paclitaxel-Laden Triazine Dendrimers

The antitumor activities of triazine dendrimers bearing paclitaxel, a well-known mitotic inhibitor, are evaluated in SCID mice bearing human prostate cancer xenografts. To increase the activity of a first generation prodrug 1 that contained twelve paclitaxel molecules tethered via an ester linkage,...

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Bibliographic Details
Published in:Mol Pharm
Main Authors: Lim, Jongdoo, Lo, Su-Tang, Hill, Sonia, Pavan, Giovanni M., Sun, Xiankai, Simanek, Eric E.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768605/
https://ncbi.nlm.nih.gov/pubmed/22260328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp2005017
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