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Comparative Cytochrome P450 In Vitro Inhibition by Atypical Antipsychotic Drugs
The goal of this study was to assess in human liver microsomes the inhibitory capacity of commonly used antipsychotics on the most prominent CYP450 drug metabolizing enzymes (CYP1A2, CYP2C9, CYP2D6, and CYP3A). Chlorpromazine was the only antipsychotic that inhibited CYP1A2 activity (IC(50) = 9.5 μM...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Hindawi Publishing Corporation
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3586484/ https://ncbi.nlm.nih.gov/pubmed/23476805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/792456 |
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