Human ADPKD primary cyst epithelial cells with a novel PKD1 mutation exhibit defective ciliary polycystin localization and loss of flow-induced Ca(2+) signaling

ADPKD gene products polycystin-1 (PC1) and polycystin-2 (PC2) colocalize in the apical monocilia of renal epithelial cells. Mouse and human renal cells without PC1 protein show impaired ciliary mechanosensation, and this impairment has been proposed to promote cystogenesis. However, most cyst epithe...

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Main Authors: Xu, Chang, Rossetti, Sandro, Jiang, Lianwei, Harris, Peter C., Brown-Glaberman, Ursa, Wandinger-Ness, Angela, Bacallao, Robert, Alper, Seth L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586432/
https://ncbi.nlm.nih.gov/pubmed/17090781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00285.2006
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